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NDB ID: 6EVJ    PDB ID: 6EVJ 


Title:

CRYSTAL STRUCTURE OF BAT INFLUENZA A/H17N10 POLYMERASE WITH VIRAL RNA PROMOTER AND CAPPED RNA PRIMER

Molecular Description:

Polymerase acidic protein
RNA-directed RNA polymerase catalytic subunit
Polymerase basic protein 2/RNA Complex

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Pflug, A., Gaudon, S., Resa-Infante, P., Lethier, M., Reich, S., Schulze, W.M., Cusack, S.
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. 
Nucleic Acids Res., 46, pp. 956 - 971, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 185.46   b = 286.17   c = 171.93 (Ångstroms)

α = 90.0   β = 93.27   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.20857 for 77007 reflections in the resolution range 50.0 to 3.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)