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NDB ID: 6BLW    PDB ID: 6BLW 


Title:

ZINC FINGER DOMAIN OF WT1(+KTS FORM) WITH M342R MUTATION AND 17+1MER OLIGONUCLEOTIDE WITH TRIPLET GGT

Molecular Description:

Wilms tumor protein/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, D., Horton, J.R., Zheng, Y., Blumenthal, R.M., Zhang, X., Cheng, X.
Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. 
Nucleic Acids Res., 46, pp. 3864 - 3877, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 63.552   b = 95.572   c = 83.34 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2233 for 21595 reflections in the resolution range 29.691 to 1.835 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)