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NDB ID: 6B0P    PDB ID: 6B0P 


Title:

ZINC FINGER DOMAIN OF WT1(-KTS FORM) WITH 12+1MER OLIGONUCLEOTIDE WITH 3' TRIPLET GGT

Molecular Description:

Wilms tumor protein/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, D., Horton, J.R., Zheng, Y., Blumenthal, R.M., Zhang, X., Cheng, X.
Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites. 
Nucleic Acids Res., 46, pp. 3864 - 3877, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 75.798   b = 84.402   c = 85.968 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1896 for 33860 reflections in the resolution range 37.883 to 2.077 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)