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NDB ID: 5XZG    PDB ID: 5XZG 


Title:

MOUSE CGAS BOUND TO THE INHIBITOR RU521

Molecular Description:

Cyclic GMP-AMP synthase/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D.J., Glickman, J.F., Ascano, M.
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. 
Nat Commun, 8, pp. 750 - 750, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 85.562   b = 98.43   c = 130.372 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1958 for 45239 reflections in the resolution range 49.215 to 1.828 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)