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NDB ID: 5X22    PDB ID: 5X22 


Title:

CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX WITH GPA AND CMPCPP

Molecular Description:

DNA-directed RNA polymerase subunit alpha
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
DNA-directed RNA polymerase subunit omega
RNA polymerase sigma factor SigA/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 5 protein sequences

Primary Citation:

Maffioli, S.I., Zhang, Y., Degen, D., Carzaniga, T., Del Gatto, G., Serina, S., Monciardini, P., Mazzetti, C., Guglierame, P., Candiani, G., Chiriac, A.I., Facchetti, G., Kaltofen, P., Sahl, H.G., Deho, G., Donadio, S., Ebright, R.H.
Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. 
Cell, 169, pp. 1240 - 1248.e23, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 186.41   b = 104.32   c = 297.29 (Ångstroms)

α = 90.0   β = 98.36   γ = 90.0 (degrees)

Refinement:

The structure was refined using the program. The R value is 0.21 for 147764 reflections in the resolution range 49.022 to 3.35 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)