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NDB ID: 5VA0    PDB ID: 5VA0 


Title:

GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN IN COMPLEX WITH AP-1 RESPONSE ELEMENT FROM VCAM-1 PROMOTER

Molecular Description:

Nuclear receptor subfamily 6 group A member 1/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Weikum, E.R., de Vera, I.M.S., Nwachukwu, J.C., Hudson, W.H., Nettles, K.W., Kojetin, D.J., Ortlund, E.A.
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. 
Nucleic Acids Res., , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 39.442   b = 96.28   c = 105.223 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1999 for 17533 reflections in the resolution range 34.483 to 2.295 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)