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NDB ID: 5ULX    PDB ID: 5ULX 


Title:

STRUCTURE OF HUMAN DNA POLYMERASE IOTA BOUND TO TEMPLATE 1-METHYL-DEOXYADENOSINE CRYSTALLIZED IN THE PRESENCE OF DCTP

Molecular Description:

DNA polymerase iota/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jain, R., Choudhury, J.R., Buku, A., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota. 
Sci Rep, 7, pp. 43904 - 43904, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 97.915   b = 97.915   c = 202.239 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX 1.10.1_2155 program. The R value is 0.217 for 41847 reflections in the resolution range 48.96 to 1.96 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)