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NDB ID: 5UC6    PDB ID: 5UC6 


Title:

STRUCTURAL INSIGHTS INTO IL-1 ALPHA RECOGNITION BY A NAPHTHYL-MODIFIED APTAMER THAT MIMICS IL-1RI DOMAIN III

Molecular Description:

Interleukin-1 alpha/DNA Complex

Structural Keywords:

, BASE TETRAPLEX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ren, X., Gelinas, A.D., von Carlowitz, I., Janjic, N., Pyle, A.M.
Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. 
Nat Commun, 8, pp. 810 - 810, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 74.79   b = 74.79   c = 86.36 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1794 for 16627 reflections in the resolution range 64.77 to 2.1 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)