A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 19-Apr-2017 number of released structures: 8825
Search for released structures

NDB ID: 5TXP    PDB ID: 5TXP 


Title:

STRUCTURE OF Q151M COMPLEX (A62V, V75I, F77L, F116Y, Q151M) MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OPEN HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.M., Arnold, E.
Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex that Confer Multi-Nucleoside Drug Resistance 
Antimicrob.Agents Chemother., , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.945   b = 133.273   c = 139.062 (Ångstroms)

α = 90.0   β = 97.59   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (1.10_2155: ???) program. The R value is 0.197 for 89184 reflections in the resolution range 37.618 to 2.7 Ångstroms with Fobs >  1.37 sigma(Fobs) and with I >  0.0 sigma(I)