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NDB ID: 5TVP    PDB ID: 5TVP 


Title:

SUMO2 BOUND TO MOUSE TDP2 CATALYTIC DOMAIN WITH A 5'-PHOSPHORYLATED DNA TERNARY COMPLEX

Molecular Description:

Tyrosyl-DNA phosphodiesterase 2/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Schellenberg, M.J., Lieberman, J.A., Herrero-Ruiz, A., Butler, L.R., Williams, J.G., Munoz-Cabello, A.M., Mueller, G.A., London, R.E., Cortes-Ledesma, F., Williams, R.S.
ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. 
Science, 357, pp. 1412 - 1416, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 106.547   b = 113.772   c = 125.434 (Ångstroms)

α = 90.0   β = 91.52   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.193 for 115887 reflections in the resolution range 49.273 to 2.399 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)