A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 15-Nov-2017 number of released structures: 9208
Search for released structures

NDB ID: 5OR0    PDB ID: 5OR0 


Title:

NMR DERIVED MODEL OF THE 5'-SPLICE SITE OF SMN2 IN COMPLEX WITH THE 5'-END OF U1 SNRNA

Molecular Description:

RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3')
RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3')

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Sivaramakrishnan, M., McCarthy, K.D., Campagne, S., Huber, S., Meier, S., Augustin, A., Heckel, T., Meistermann, H., Hug, M.N., Birrer, P., Moursy, A., Khawaja, S., Schmucki, R., Berntenis, N., Giroud, N., Golling, S., Tzouros, N., Banfai, B., Duran-Pacheco, G., Lamerz, J., Hsiu Liu, Y., Luebbers, T., Ratni, A., Ebeling, M., Clery, A., Paushkin, S., Krainer, A.R., Allain, F.H., Metzger, F.
Binding to SMN2 pre-mRNA-Protein complex elicits specificity for small molecule splicing modifiers 
Nat Commun, , pp. - , 2017.

Experimental Information:

SOLUTION NMR

Cell Constants:

a =   b =   c = (Ångstroms)

α =   β =   γ = (degrees)

Number of Models:

Number of Models: 10 Structures

Sample Details:

1 mM RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), 1 mM RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3'), 10 mM deuterated MES, 50 mM sodium chloride, 100% D2O 100% D2O