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NDB ID: 5NW9    PDB ID: 5NW9 


Title:

CRYSTAL STRUCTURE OF THE COMPLEX OF TDP1 WITH DUPLEX DNA

Molecular Description:

Tyrosyl-DNA phosphodiesterase 1/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Flett, F.J., Ruksenaite, E., Armstrong, L.A., Bharati, S., Carloni, R., Morris, E.R., Mackay, C.L., Interthal, H., Richardson, J.M.
Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1. 
Nat Commun, 9, pp. 24 - 24, 2018.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 108.01   b = 195.31   c = 50.83 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2338 for 65640 reflections in the resolution range 52.05 to 2.04 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)