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NDB ID: 5NDW    PDB ID: 5NDW 


Title:

CRYSTAL STRUCTURE OF AMINOGLYCOSIDE TC007 BOUND TO THE YEAST 80S RIBOSOME

Molecular Description:

40S ribosomal protein S10-A
40S ribosomal protein S11-A
40S ribosomal protein S12
40S ribosomal protein S13
40S ribosomal protein S14-B
40S ribosomal protein S15
40S ribosomal protein S16-A
40S ribosomal protein S17-A
40S ribosomal protein S18-A
40S ribosomal protein S19-A
40S ribosomal protein S20
40S ribosomal protein S21-A
40S ribosomal protein S22-A
40S ribosomal protein S23-A
40S ribosomal protein S24-A
40S ribosomal protein S25-A
40S ribosomal protein S26-B
40S ribosomal protein S27-A
40S ribosomal protein S28-A
40S ribosomal protein S29-A
40S ribosomal protein S30-A
Ubiquitin-40S ribosomal protein S31
60S ribosomal protein L2-A
60S ribosomal protein L3
60S ribosomal protein L4-A
60S ribosomal protein L5
60S ribosomal protein L6-A
60S ribosomal protein L7-A
60S ribosomal protein L8-A
60S ribosomal protein L9-A
60S ribosomal protein L10
60S ribosomal protein L11-B
60S ribosomal protein L13-A
60S ribosomal protein L14-A
60S ribosomal protein L15-A
60S ribosomal protein L16-A
60S ribosomal protein L17-A
60S ribosomal protein L18-A
60S ribosomal protein L19-A
60S ribosomal protein L20-A
60S ribosomal protein L21-A
60S ribosomal protein L22-A
60S ribosomal protein L23-A
60S ribosomal protein L24-A
60S ribosomal protein L25
60S ribosomal protein L26-A
60S ribosomal protein L27-A
60S ribosomal protein L28
60S ribosomal protein L29
60S ribosomal protein L30
60S ribosomal protein L31-A
60S ribosomal protein L32
60S ribosomal protein L33-A
60S ribosomal protein L34-A
60S ribosomal protein L35-A
60S ribosomal protein L36-A
60S ribosomal protein L37-A
60S ribosomal protein L38
60S ribosomal protein L39
Ubiquitin-60S ribosomal protein L40
60S ribosomal protein L41-A
60S ribosomal protein L42-A
60S ribosomal protein L43-A
40S ribosomal protein S0-A
40S ribosomal protein S1-A
40S ribosomal protein S2
40S ribosomal protein S3
40S ribosomal protein S4-A
40S ribosomal protein S5
40S ribosomal protein S6-A
40S ribosomal protein S7-A
40S ribosomal protein S8-A
40S ribosomal protein S9-A
Suppressor protein STM1
Guanine nucleotide-binding protein subunit beta-like protein/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 4 nucleic acid sequences

Protein Sequence:

Click to show/hide 75 protein sequences

Primary Citation:

Prokhorova, I., Altman, R.B., Djumagulov, M., Shrestha, J.P., Urzhumtsev, A., Ferguson, A., Chang, C.T., Yusupov, M., Blanchard, S.C., Yusupova, G.
Aminoglycoside interactions and impacts on the eukaryotic ribosome. 
Proc. Natl. Acad. Sci. U.S.A., 114, pp. E10899 - E10908, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 442.14   b = 298.76   c = 299.77 (Ångstroms)

α = 90.0   β = 99.49   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1927 for 814312 reflections in the resolution range 147.832 to 3.7 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)