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NDB ID: 5NDK    PDB ID: 5NDK 


Title:

CRYSTAL STRUCTURE OF AMINOGLYCOSIDE TC007 CO-CRYSTALLIZED WITH 70S RIBOSOME FROM THERMUS THERMOPHILUS, THREE TRNAS AND MRNA

Molecular Description:

50S ribosomal protein L18
50S ribosomal protein L23
50S ribosomal protein L2
50S ribosomal protein L34
30S ribosomal protein S11
30S ribosomal protein S17
30S ribosomal protein S3
30S ribosomal protein S9
50S ribosomal protein L13
50S ribosomal protein L24
50S ribosomal protein L35
30S ribosomal protein S12
30S ribosomal protein S4
50S ribosomal protein L19
50S ribosomal protein L30
50S ribosomal protein L9
30S ribosomal protein S18
30S ribosomal protein Thx
50S ribosomal protein L14
50S ribosomal protein L25
50S ribosomal protein L3
30S ribosomal protein S13
30S ribosomal protein S5
50S ribosomal protein L20
50S ribosomal protein L31
30S ribosomal protein S19
50S ribosomal protein L15
50S ribosomal protein L27
50S ribosomal protein L4
30S ribosomal protein S14 type Z
30S ribosomal protein S6
50S ribosomal protein L21
50S ribosomal protein L32
30S ribosomal protein S20
50S ribosomal protein L16
50S ribosomal protein L28
50S ribosomal protein L5
30S ribosomal protein S15
30S ribosomal protein S7
50S ribosomal protein L22
30S ribosomal protein S2
50S ribosomal protein L17
50S ribosomal protein L29
50S ribosomal protein L6
30S ribosomal protein S10
30S ribosomal protein S16
30S ribosomal protein S8/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 5 nucleic acid sequences

Protein Sequence:

Click to show/hide 47 protein sequences

Primary Citation:

Prokhorova, I., Altman, R.B., Djumagulov, M., Shrestha, J.P., Urzhumtsev, A., Ferguson, A., Chang, C.T., Yusupov, M., Blanchard, S.C., Yusupova, G.
Aminoglycoside interactions and impacts on the eukaryotic ribosome. 
Proc. Natl. Acad. Sci. U.S.A., 114, pp. E10899 - E10908, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 209.07   b = 447.36   c = 619.49 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2135 for 1203750 reflections in the resolution range 152.739 to 2.95 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)