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NDB ID: 5N6I    PDB ID: 5N6I 


Title:

CRYSTAL STRUCTURE OF MOUSE CGAS IN COMPLEX WITH 39 BP DNA

Molecular Description:

Cyclic GMP-AMP synthase/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Andreeva, L., Hiller, B., Kostrewa, D., Lassig, C., de Oliveira Mann, C.C., Drexler, D.J., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., Hopfner, K.-P.
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders 
Nature, , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 168.53   b = 122.94   c = 179.98 (Ångstroms)

α = 90.0   β = 96.37   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.20646 for 26998 reflections in the resolution range 47.0 to 3.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)