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NDB ID: 5MEI    PDB ID: 5MEI 


Title:

CRYSTAL STRUCTURE OF AGELASTATIN A BOUND TO THE 80S RIBOSOME

Molecular Description:

60S ribosomal protein L2-A
60S ribosomal protein L3
60S ribosomal protein L4-A
60S ribosomal protein L5
60S ribosomal protein L6-A
60S ribosomal protein L7-A
60S ribosomal protein L8-A
60S ribosomal protein L9-A
60S ribosomal protein L10
60S ribosomal protein L11-B
60S ribosomal protein L13-A
60S ribosomal protein L14-A
60S ribosomal protein L15-A
60S ribosomal protein L16-A
60S ribosomal protein L17-A
60S ribosomal protein L18-A
60S ribosomal protein L19-A
60S ribosomal protein L20-A
60S ribosomal protein L21-A
60S ribosomal protein L22-A
60S ribosomal protein L23-A
60S ribosomal protein L24-A
60S ribosomal protein L25
60S ribosomal protein L26-A
60S ribosomal protein L27-A
60S ribosomal protein L28
60S ribosomal protein L29
60S ribosomal protein L30
60S ribosomal protein L31-A
60S ribosomal protein L32
60S ribosomal protein L33-A
60S ribosomal protein L34-A
60S ribosomal protein L35-A
60S ribosomal protein L36-A
60S ribosomal protein L37-A
60S ribosomal protein L38
60S ribosomal protein L39
Ubiquitin-60S ribosomal protein L40
60S ribosomal protein L41-B
60S ribosomal protein L42-A
60S ribosomal protein L43-A
Suppressor protein STM1
60S acidic ribosomal protein P0
Suppressor protein STM1
Suppressor protein Stm1 - Mol B
40S ribosomal protein S0-A
40S ribosomal protein S1-A
40S ribosomal protein S2
40S ribosomal protein S3
40S ribosomal protein S4-A
40S ribosomal protein S5
40S ribosomal protein S6-A
40S ribosomal protein S7-A
40S ribosomal protein S8
40S ribosomal protein S9-A
40S ribosomal protein S10-A
40S ribosomal protein S11-A
40S ribosomal protein S12
40S ribosomal protein S13
40S ribosomal protein S14-B
40S ribosomal protein S15
40S ribosomal protein S16-A
ES17
40S ribosomal protein S18-A
40S ribosomal protein S19-A
40S ribosomal protein S20
40S ribosomal protein S21-A
40S ribosomal protein S22-A
40S ribosomal protein S23-A
40S ribosomal protein S24-A
40S ribosomal protein S25-A
40S ribosomal protein S26-B
40S ribosomal protein S27-A
40S ribosomal protein S28-A
40S ribosomal protein S29-A
40S ribosomal protein S30-A
Ubiquitin-40S ribosomal protein S31
Guanine nucleotide-binding protein subunit beta-like protein
40S ribosomal protein S17-B/RNA Complex

Nucleic Acid Sequence:

Click to show/hide 4 nucleic acid sequences

Protein Sequence:

Click to show/hide 79 protein sequences

Primary Citation:

McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J.C.P., Lu, J., Guo, Z., Ayinde, S., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R., Liu, J.O.
Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. 
Cell Chem Biol, 24, pp. 605 - 613.e5, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 304.08   b = 286.55   c = 436.55 (Ångstroms)

α = 90.0   β = 99.05   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1962 for 925645 reflections in the resolution range 98.383 to 3.5 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)