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NDB ID: 5GWK    PDB ID: 5GWK 


Title:

HUMAN TOPOISOMERASE IIALPHA IN COMPLEX WITH DNA AND ETOPOSIDE

Molecular Description:

DNA topoisomerase 2-alpha (E.C.5.99.1.3)/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, Y.R., Chen, S.F., Wu, C.C., Liao, Y.W., Lin, T.S., Liu, K.T., Chen, Y.S., Li, T.K., Chien, T.C., Chan, N.L.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry 
Nucleic Acids Res., 45, pp. 10861 - 10871, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 2 21

Cell Constants:

a = 105.113   b = 126.155   c = 198.856 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2046 for 45898 reflections in the resolution range 27.488 to 3.152 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)